Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Prospects for intranasal drug delivery systems with Ginkgo biloba in the treatment of cerebral circulatory disorders

N D Bunyatyan^1,3, E V Kovtun² , I A Samylina¹, E F Stepanova², Yu V Olefir³, L A Korol¹, A B Prokofiev^1,3, V A Evteev³, D O Bokov¹

¹Sechenov First Moscow State Medical University, 8 Trubetskaya St, Moscow, 119991; ²Pyatigorsk Medical and Pharmaceutical Institute Branch of Volgograd State Medical University, 11, Kalinin Avenue, Pyatigorsk, Stavropol Territory 357532; ³Federal State Budgetary Institution â€œScientific Centre for Expert Evaluation of Medicinal Productsâ€ of the Ministry of Health of the Russian Federation, 8/2 Petrovsky Boulevard, Moscow 127051, Russia.

For correspondence:- E Kovtun Email: elena.f.73@mail.ru

Accepted: 28 October 2019 Published: 30 November 2019

Citation: Bunyatyan ND, Kovtun EV, Samylina IA, Stepanova EF, Olefir YV, Korol LA, et al. Prospects for intranasal drug delivery systems with Ginkgo biloba in the treatment of cerebral circulatory disorders. Trop J Pharm Res 2019; 18(11):2233-2240 doi: 10.4314/tjpr.v18i11.1

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To analyze the range of currently available nasal medicines, and to study extant information on the use of Ginkgo biloba herbal complexes for the treatment of cerebral circulatory disorders of different etiologies. The study dwelt on the features and prospects of intranasal drug administration. Currently, intranasal administration is used primarily for the treatment of local symptoms. However, it has a much higher potential: the mucous membrane of the nasal cavity offers an opportunity for non-invasive treatment using systemic administration.

Methods: The study involved the analysis of materials from information-retrieval systems, library databases, patent databases, and scientific information repositories such as e-Library. PubMed, Scopus, Google Scholar, as well as materials from the websites of manufacturers of herbal medicinal products and other herbal substances.

Results: Herbal medicinal products have great potential in terms of intranasal administration. This is especially true of herbal medicines obtained through extraction of leaves of Ginkgo biloba, which have a broad spectrum of action, i.e., anti-aggregatory, venotonic, nootropic, anti-hypoxic, antioxidant, anti-inflammatory, membrane-stabilizing, and capillary-protective effects. The range of Ginkgo biloba-based medicines calls for expansion, and this testifies to a good potential of these products in terms of further research and use. The analysis of literature and technical information showed the existence of a wide range of nasal medicines currently in use. However, only few drugs are used for the treatment of cerebrovascular diseases. Furthermore, there are no herbal medicines among these drugs, despite obvious advantages of herbal products such as ease of use, high bioavailability, and systemic action potential.

Conclusion: The current status of research on nasal dosage forms of Ginkgo biloba herbal complexes warrants further development involving biopharmaceutical and pharmacological studies.

Keywords: Nasal dosage forms, Cerebral circulation disorder, Ginkgo biloba